In rare cases, the drug interferon alpha therapy, including , in combination with ribavirin is associated with pancytopenia; very rarely – with aplastic anemia.
Antibodies to interferon. In some patients after the administration of drugs containing a homologous protein may be produced neutralizing antibodies active protein. It is therefore likely that a certain proportion of patients will be detected antibodies to all interferons, both natural and recombinant. In some diseases (cancer, systemic lupus erythematosus, herpes zoster) antibodies to human leukocyte interferon may occur spontaneously in patients who have never been treated with interferon. Indications that in any clinical indications of the presence of such antibodies can affect patient response to Roferon ® -A is not available.
In combination therapy with ribavirin – see also the side effects of ribavirin..
Pre-clinical study. In rhesus monkeys, who were prescribed doses far exceeding recommended for clinics, observed transient menstrual irregularities, including the extension of the period of menstruation.
As with other alpha interferons, in patients treated with sustanon side effects, cases of transplant rejection have been observed.
Interaction with other drugs
Interferons alpha can disrupt the oxidative metabolic processes, reducing the activity of hepatic microsomal enzymes of the cytochrome P450 system. This should be considered, while the appointment of drugs that are metabolized by the data. Described decrease theophylline clearance after co-administration of interferon alpha.
Interferons may exacerbate neurotoxicity, haematological or cardiotoxic effects of drugs prescribed before or simultaneously with them. The interactions can be observed after co-administration of centrally acting drugs.
In combination therapy with ribavirin – see also the interaction of ribavirin..
Avastin (bevacizumab) has no significant effect on the pharmacokinetics of interferon alfa-2a.
Features of the drug by pregnant women sustanon side effects, women during the period of breastfeeding, children and adults with chronic diseases
Pregnancy and breast-feeding
Men and women receiving should use reliable methods of contraception. In pregnancy, the drug should be administered only if the benefit of treatment exceeds the potential risk to the fetus.Although animal studies do not indicate a teratogenic drug, we can not exclude the possibility that its use during pregnancy can harm the fetus. When rhesus monkeys in the early and middle stages of pregnancy were administered doses greatly exceeding the recommended for the clinic, they have noted an increase in the number of abortions.
Benzyl alcohol is contained as a filler, can cross the placenta. In appointing the drug solution just before birth or caesarean delivery should be aware of toxic effects on premature babies.
Pregnant women should not usesustanon side effectsin combination with ribavirin. Women of childbearing age and the male partners of women of childbearing age receiving in combination with ribavirin should use reliable methods of contraception (see. Also on the use of ribavirin instructions).
is unknown whether sustanon side effects breast milk. The question of the cessation of breast-feeding, or the abolition of the drug should be decided depending on the importance of treatment to the mother.
Effects on ability to drive and use machines
Depending on the dosing regimen and individual sensitivity of the patient, may have effects on the reaction rate, affecting the performance of certain operations, such as driving vehicles, working with machines and mechanisms.