If you intend to communicate cardiomyopathy develop during treatment with therapy with interferon beta-1b, treatment should be discontinued. The use of cytokines in patients with sustanon 250 side effects monoclonal gammopathy is sometimes accompanied by the development syndrome of systemic capillary permeability increase with shock-like symptoms and fatal outcome.
Pregnancy and lactation It is not known whether interferon capable of beta-1b to cause damage to the fetus in the treatment of pregnant women or affect human reproduction. In controlled clinical trials in patients with multiple sclerosis have been cases of spontaneous abortion. Studies in rhesus monkeys a human interferon beta-1b has embryotoxic effects bradley martin steroids in higher doses caused an increase in the frequency of abortion.Consequently, interferon beta-1b is contraindicated in pregnancy. Women of reproductive age in the treatment of this drug should use adequate contraception methods. In case of pregnancy during treatment with interferon beta-1b, or planning a pregnancy, a woman should be informed about the potential risks and recommend discontinuation of treatment. It is not known if excreted interferon beta-1b in breast milk. Given the potential for serious adverse reactions to Interferon beta-1b in infants who are breastfed, you must stop breast-feeding or stop the drug.
Side effects: During the registration clinical trial sustanon 250 side effects were observed following adverse events: Common reactions: Complex flu-like symptoms, fever, chills. Local reactions: . Reaction at the injection site, pain at the injection site Cardiovascular system: high blood pressure. blood and lymphatic system: anemia, lymphopenia. Metabolic and nutritional disorders: increase the level of enzymes in the blood: increased TSH level, aspartate aminotransferase (AST) to 4 times the original, alanine aminotransferase (ALT) to 4 times the original. Nervous system: anxiety. Musculoskeletal system: myalgia. Skin: . rash makulezno-papular character of the application of other preparations of interferon beta-1b was observed The following adverse events: General disorders and reactions at the injection site: injection-site reaction, asthenia (weakness), a complex of flu-like symptoms, headache, fever, chills, abdominal pain, chest pain, pain of various localization, malaise, necrosis at the injection site. Cardiovascular system:peripheral edema, vasodilatation, peripheral vascular disease, hypertension, palpitations, tachycardia.
Musculoskeletal System: myasthenia, arthralgia, myalgia, leg cramps. Nervous sustanon 250 side effects system: hypertonicity, dizziness, insomnia, impaired coordination, anxiety, nervousness. Respiratory system: shortness of breath. Skin: rash, skin diseases, increased sweating, . alopecia Urogenital: urgency to urinate, frequent urination in women – metrorrhagia (acyclic bleeding), menorrhagia (prolonged menstrual bleeding), dysmenorrhea (painful periods), men – impotence, prostate disease. In the post-marketing studies have been reported following side effects of other drugs interferon beta-1b (frequency of side effects is classified as follows: very common. General reactions: very common: flu-like symptoms (fever, chills, myalgia, headache, or sweating). The frequency of these symptoms decreased over time. Rare: malaise, chest pain, weight loss. Local reactions: very common: injection site reactions (redness, local edema), inflammation, and pain. Uncommon: skin necrosis. Over time, with continued treatment frequency of reactions at the site of injection is usually reduced. Blood and Lymphatic System: Uncommon: anemia, thrombocytopenia, leukopenia. Rare: lymphadenopathy. Endocrine disorders: rare: thyroid dysfunction, hyperthyroidism, hypothyroidism. Metabolic disorders: rare: elevated triglycerides. Nervous system: Uncommon: muscular hypertonicity, depression. Rare: convulsions, confusion, agitation, emotional lability, suicide attempts, anorexia. Cardiovascular system: Uncommon: hypertension. Rare: cardiomyopathy, tachycardia, palpitations. Respiratory system: rare: dyspnea, bronchospasm. Gastrointestinal: rarely : nausea and vomiting. Rare: pancreatitis. Liver and biliary ways: rare: increased activity sustanon 250 side effects. Rare: increase of activity, bilirubin, hepatitis. Skin and subcutaneous tissue: Uncommon: alopecia, rash, itchy skin, skin rashes. Rare:. Skin discoloration, excessive sweating skeletal muscle: uncommon:. Myalgia female reproductive system: rare: menstrual disorders. Allergic reactions: rare: anaphylactic reactions.
Overdose Interferon beta-1b in doses of up to 176 million. IU intravenously three times a week in adult patients with malignant tumors caused no serious adverse events.
Interaction with other drugs in the treatment of exacerbations of the disease in patients treated with interferon beta-1b, tolerability corticosteroids or ACTH, which was used for up to 28 days, was good. Application together with other immunosuppressants, corticosteroids and ACTH in addition, has not been studied. In-interferons reduced the activity of hepatic cytochrome P450-dependent enzymes in humans and animals. Care must be taken when administered in conjunction with drugs having a narrow therapeutic index, the clearance of which largely depends on the hepatic cytochrome P450 (eg, antiepileptics). Care must be taken while the use of any drug affecting blood formation system.
Effect on ability to drive vehicles and maintenance mechanisms Given the mechanism of pharmacological action of interferon-beta-1b, its direct impact on the ability to drive and use machines is highly unlikely. However, the side effects observed in the central nervous system associated with the use of interferon-beta-1b, in susceptible individuals can affect the ability to drive or operate machinery.
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